Prognosis Of Pediatric Osteosarcoma: Risk Factors And Analysis Analysis
DOI:
https://doi.org/10.5281/zenodo.14182140Keywords:
Diagnosis, Risk Factors, Osteosarcoma, Pediatrics, SurvivalAbstract
The study reviewed the literature on risk factors and prognosis of pediatric osteosarcoma, focusing on the influence of these factors on survival analysis. Using integrative review methodology and following PRISMA guidelines. The most frequently cited risk factors included the presence of metastasis at diagnosis, inadequate response to chemotherapy, advanced age at diagnosis and aggressive tumor characteristics such as permeative margins and significant tumor necrosis. The analysis showed that these factors are associated with worse overall survival and event-free survival, negatively impacting prognosis. It was also found that cardiotoxicity, especially in patients treated with doxorubicin, is an emerging risk factor that requires close monitoring. The conclusion of the study highlights the importance of early identification and monitoring of risk factors in order to improve treatment and clinical outcomes in pediatric patients. The research suggests that future studies should investigate therapeutic and diagnostic approaches that reduce the risks and improve the survival rates of these patients.
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