CONEXÕES CORAÇÃO-CÉREBRO: FIBRILAÇÃO ATRIAL (FA), DEMÊNCIA E DECLÍNIO COGNITIVO
DOI:
https://doi.org/10.71248/sa4czq48Palavras-chave:
Demência, Doença de Alzheimer, Fibrilação AtrialResumo
Este artigo tem como objetivo realizar uma revisão bibliográfica para relatar as conexões da Fibrilação Atrial (FA) com doenças neurovasculares como demência, Doença de Alzheimer (DA) e Doença de Parkinson (DP), além da já estabelecida associação com o acidente vascular cerebral (AVC) isquêmico, abrangendo também infartos cerebrais silenciosos e marcadores de doença de pequenos vasos. As bases de dados científicos usadas foram: Scientific Electronic Library Online (Scielo), National Library of Medicine (NIH), PubMed pelos Descritores em Ciências da Saúde (DeCS) utilizando-se palavras-chave como “Fibrilação Atrial”, “Doença de Alzheimer”, “Doença de Parkinson”, “Demência”, se fez uso do operador booleano AND. Artigos utilizados forma de 2020 a 2025. A hipoperfusão cerebral e a inflamação persistente contribuem para a neurodegeneração, ao passo que a doença cerebral de pequenos vasos (DRCV) e microssangramentos que estão fortemente associados à demência vascular e DA. Por conseguinte, a FA está associada a doenças neurodegenerativas, como Alzheimer e Parkinson, ao induzir hipoperfusão e inflamação crônica, acelerando o acúmulo da proteína β-amiloide e da proteína tau. Pode-se concluir que essa arritmia pode não apenas favorecer o comprometimento cognitivo de origem vascular, mas também intensificar processos neuroinflamatórios e a deposição de proteína amiloide, contribuindo para a progressão da neurodegeneração.
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